Bruising after Diphenhydramine in dogs

The FDA has received 76 reports of bruising in dogs after Diphenhydramine. That is 1.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

76Reports
72%Marked serious
16%Recovered
28%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
23 40%
1–2 days
6 11%
3–7 days
10 18%
1–4 weeks
7 12%
Over a month
11 19%

How the animals did

Recovered
12 16%
Still unwell when reported
27 36%
Died
6 7.9%
Euthanised
15 20%
Not known
16 21%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
11
4–7 years
28
8–11 years
23
12+ years
10

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause bruising in dogs?
76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bruising with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with bruising