Abnormal ultrasound finding after Diphenhydramine in dogs

87 reports to the FDA describe abnormal ultrasound finding in dogs given Diphenhydramine. That is 1.8% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

87Reports

87%Marked serious

11%Recovered

43%Died or euthanised

1 daysTypical onset

How soon it started

Same day

31 41%

1–2 days

13 17%

3–7 days

6 8.0%

1–4 weeks

7 9.3%

Over a month

18 24%

How the animals did

Recovered

10 11%

Still unwell when reported

38 44%

Died

17 20%

Euthanised

20 23%

Not known

2 2.3%

Problems reported at the same time

54 62%

53 61%

44 51%

40 46%

37 43%

33 38%

33 38%

31 36%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause abnormal ultrasound finding in dogs?: 87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal ultrasound finding with similar medicines

Abnormal ultrasound finding after Melarsomine (Immiticide) 64 reports · 0.3% of its reports
Abnormal ultrasound finding after Polysulfated Glycosaminoglycan 118 reports · 2.2% of its reports
Abnormal ultrasound finding after Butorphanol 96 reports · 2.2% of its reports
Abnormal ultrasound finding after Cefpodoxime 114 reports · 2.8% of its reports
Abnormal ultrasound finding after Tramadol 189 reports · 5.0% of its reports
Abnormal ultrasound finding after Desoxycorticosterone Pivalate 35 reports · 1.0% of its reports
Abnormal ultrasound finding after Propofol 61 reports · 2.0% of its reports
Abnormal ultrasound finding after Isoflurane 74 reports · 2.7% of its reports
Abnormal ultrasound finding after Cephalexin 47 reports · 1.8% of its reports
Abnormal ultrasound finding after Atipamezole 33 reports · 1.2% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with abnormal ultrasound finding