Breathing problems after Cyphenothrin + Fipronil in dogs

27 reports to the FDA describe breathing problems in dogs given Cyphenothrin + Fipronil. That is 9.4% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

27Reports

67%Marked serious

70%Recovered

7.4%Died or euthanised

Same dayTypical onset

How soon it started

Same day

11 65%

1–2 days

1 5.9%

3–7 days

1 5.9%

1–4 weeks

1 5.9%

Over a month

3 18%

How the animals did

Recovered

19 70%

Still unwell when reported

2 7.4%

Euthanised

2 7.4%

Not known

4 15%

Problems reported at the same time

Restlessness or agitation

14 52%

Lethargy

13 48%

Itching

12 44%

Vocalising

9 33%

Anxiety

6 22%

Fever

4 15%

Loss of appetite

4 15%

Tachycardia

3 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fipronil kills fleas and ticks (spot-on).

Questions owners ask

Can Cyphenothrin + Fipronil cause breathing problems in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

Breathing problems after Spinosad (Comfortis) 748 reports · 1.3% of its reports
Breathing problems after Lufenuron + Milbemycin Oxime (Sentinel) 393 reports · 1.5% of its reports
Breathing problems after Imidacloprid + Moxidectin (Advantage Multi) 499 reports · 3.8% of its reports
Breathing problems after Nitenpyram (Capstar) 472 reports · 4.4% of its reports
Breathing problems after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 137 reports · 1.4% of its reports
Breathing problems after Fipronil + S-methoprene (Frontline Plus) 132 reports · 4.5% of its reports
Breathing problems after Flumethrin + Imidacloprid (Seresto) 73 reports · 3.2% of its reports
Breathing problems after Imidacloprid 54 reports · 2.8% of its reports
Breathing problems after Fipronil 64 reports · 4.5% of its reports
Breathing problems after Imidacloprid + Permethrin + Pyriproxyfen 34 reports · 4.6% of its reports

All reported side effects of Cyphenothrin + Fipronil in dogs · Medicines most reported with breathing problems