Neoplasia after Cyclosporine (Atopica) in dogs

136 reports to the FDA describe neoplasia in dogs given Cyclosporine. That is 0.9% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

136Reports
40%Marked serious
4.4%Recovered
21%Died or euthanised
65 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
3 10%
1–2 days
3 10%
3–7 days
1 3.4%
1–4 weeks
2 6.9%
Over a month
20 69%

How the animals did

Recovered
5 3.7%
Recovered with lasting effects
1 0.7%
Still unwell when reported
21 15%
Died
16 12%
Euthanised
12 8.8%
Not known
81 60%

Problems reported at the same time

Death
29 21%
Liver problems
17 13%
Loss of appetite
16 12%
Lethargy
16 12%
Abnormal ultrasound finding
15 11%
Vomiting
14 10%
Dermal mass
12 8.8%
Abnormal radiograph finding
10 7.4%

Age of the animals

Under 1 year
2
1–3 years
2
4–7 years
36
8–11 years
50
12+ years
37

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause neoplasia in dogs?
136 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 65 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neoplasia with similar medicines

All reported side effects of Cyclosporine in dogs · Medicines most reported with neoplasia