Elevated gamma-glutamyl transferase (ggt) after Cyclosporine (Atopica) in dogs

The FDA has received 126 reports of elevated gamma-glutamyl transferase (ggt) in dogs after Cyclosporine. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

126Reports
25%Marked serious
2.4%Recovered
21%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
2 6.9%
1–2 days
3 10%
3–7 days
2 6.9%
1–4 weeks
6 21%
Over a month
16 55%

How the animals did

Recovered
2 1.6%
Recovered with lasting effects
1 0.8%
Still unwell when reported
17 13%
Died
16 13%
Euthanised
10 7.9%
Not known
80 63%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
13
4–7 years
41
8–11 years
54
12+ years
17

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause elevated gamma-glutamyl transferase (ggt) in dogs?
126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Cyclosporine in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)