Decreased packed cell volume (pcv) after Ampicillin in dogs

The FDA has received 30 reports of decreased packed cell volume (pcv) in dogs after Ampicillin. That is 3.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

30Reports
93%Marked serious
17%Recovered
57%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
3 13%
1–2 days
1 4.2%
3–7 days
7 29%
1–4 weeks
6 25%
Over a month
7 29%

How the animals did

Recovered
5 17%
Still unwell when reported
4 13%
Died
2 6.7%
Euthanised
15 50%
Not known
4 13%

Problems reported at the same time

Loss of appetite
19 63%
Liver problems
19 63%
Lethargy
18 60%
Death
17 57%
Blood problems
16 53%
Kidney problems
15 50%
Vomiting
13 43%
Diarrhea
12 40%

Age of the animals

Under 1 year
4
1–3 years
5
4–7 years
7
8–11 years
10
12+ years
4

About this medicine

Type: medicine.

Questions owners ask

Can Ampicillin cause decreased packed cell volume (pcv) in dogs?
30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased packed cell volume (pcv) with similar medicines

All reported side effects of Ampicillin in dogs · Medicines most reported with decreased packed cell volume (pcv)