Lymphopenia after Amoxicillin in dogs

26 reports to the FDA describe lymphopenia in dogs given Amoxicillin. That is 1.9% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

88%Marked serious

3.8%Recovered

58%Died or euthanised

33 daysTypical onset

How soon it started

Same day

2 11%

1–2 days

0 0.0%

3–7 days

2 11%

1–4 weeks

5 26%

Over a month

10 53%

How the animals did

Recovered

1 3.8%

Still unwell when reported

8 31%

Died

3 12%

Euthanised

12 46%

Not known

2 7.7%

Problems reported at the same time

20 77%

15 58%

15 58%

14 54%

12 46%

10 38%

10 38%

9 35%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause lymphopenia in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 33 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lymphopenia with similar medicines

Lymphopenia after Amoxicillin + Clavulanate (Clavamox) 95 reports · 1.8% of its reports
Lymphopenia after Doxycycline 64 reports · 1.6% of its reports
Lymphopenia after Cefovecin (Convenia) 39 reports · 1.0% of its reports
Lymphopenia after Enrofloxacin (Baytril) 99 reports · 2.6% of its reports
Lymphopenia after Metronidazole 100 reports · 3.2% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with lymphopenia