Lymphopenia after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 95 reports of lymphopenia in dogs after Amoxicillin + Clavulanate. That is 1.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause lymphopenia in dogs?

95 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 9 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lymphopenia with similar medicines

• Lymphopenia after Doxycycline 64 reports · 1.6% of its reports
• Lymphopenia after Cefovecin (Convenia) 39 reports · 1.0% of its reports
• Lymphopenia after Enrofloxacin (Baytril) 99 reports · 2.6% of its reports
• Lymphopenia after Metronidazole 100 reports · 3.2% of its reports
• Lymphopenia after Amoxicillin 26 reports · 1.9% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with lymphopenia