Restlessness or agitation after Amoxicillin + Clavulanate (Clavamox) in dogs

128 reports to the FDA describe restlessness or agitation in dogs given Amoxicillin + Clavulanate. That is 2.4% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

128Reports
48%Marked serious
18%Recovered
16%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
15 17%
1–2 days
23 26%
3–7 days
14 16%
1–4 weeks
23 26%
Over a month
15 17%

How the animals did

Recovered
21 16%
Recovered with lasting effects
2 1.6%
Still unwell when reported
33 26%
Died
13 10%
Euthanised
8 6.3%
Not known
51 40%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
14
4–7 years
27
8–11 years
38
12+ years
32

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause restlessness or agitation in dogs?
128 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with restlessness or agitation