Behaviour change after Amoxicillin + Clavulanate (Clavamox) in dogs

226 reports to the FDA describe behaviour change in dogs given Amoxicillin + Clavulanate. That is 4.2% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

226Reports
46%Marked serious
17%Recovered
19%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
27 16%
1–2 days
35 21%
3–7 days
24 14%
1–4 weeks
39 23%
Over a month
41 25%

How the animals did

Recovered
35 15%
Recovered with lasting effects
4 1.8%
Still unwell when reported
74 33%
Died
21 9.3%
Euthanised
21 9.3%
Not known
71 31%

Problems reported at the same time

Age of the animals

Under 1 year
25
1–3 years
39
4–7 years
56
8–11 years
55
12+ years
50

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause behaviour change in dogs?
226 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with behaviour change