Low platelet count after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 64 reports of low platelet count in dogs after Amoxicillin + Clavulanate. That is 1.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

64Reports
86%Marked serious
11%Recovered
38%Died or euthanised
11 daysTypical onset
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How soon it started

Same day
3 5.3%
1–2 days
6 11%
3–7 days
12 21%
1–4 weeks
18 32%
Over a month
18 32%

How the animals did

Recovered
6 9.4%
Recovered with lasting effects
1 1.6%
Still unwell when reported
29 45%
Died
7 11%
Euthanised
17 27%
Not known
4 6.3%

Problems reported at the same time

Age of the animals

Under 1 year
5
1–3 years
12
4–7 years
18
8–11 years
19
12+ years
8

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause low platelet count in dogs?
64 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 11 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Low platelet count with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with low platelet count