Leucopenia after Amoxicillin + Clavulanate (Clavamox) in dogs

81 reports to the FDA describe leucopenia in dogs given Amoxicillin + Clavulanate. That is 1.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

81Reports
57%Marked serious
7.4%Recovered
27%Died or euthanised
8 daysTypical onset
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How soon it started

Same day
9 16%
1–2 days
10 18%
3–7 days
8 15%
1–4 weeks
15 27%
Over a month
13 24%

How the animals did

Recovered
6 7.4%
Still unwell when reported
34 42%
Died
7 8.6%
Euthanised
15 19%
Not known
19 23%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
15
4–7 years
30
8–11 years
20
12+ years
7

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause leucopenia in dogs?
81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 8 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with leucopenia