Leucopenia after Doxycycline in dogs

55 reports to the FDA describe leucopenia in dogs given Doxycycline. That is 1.4% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports

64%Marked serious

11%Recovered

25%Died or euthanised

35 daysTypical onset

How soon it started

Same day

3 6.7%

1–2 days

5 11%

3–7 days

6 13%

1–4 weeks

7 16%

Over a month

24 53%

How the animals did

Recovered

6 11%

Still unwell when reported

29 53%

Died

3 5.5%

Euthanised

11 20%

Not known

6 11%

Problems reported at the same time

32 58%

26 47%

23 42%

23 42%

21 38%

19 35%

16 29%

14 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause leucopenia in dogs?: 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

Leucopenia after Amoxicillin + Clavulanate (Clavamox) 81 reports · 1.5% of its reports
Leucopenia after Cefovecin (Convenia) 63 reports · 1.7% of its reports
Leucopenia after Enrofloxacin (Baytril) 81 reports · 2.1% of its reports
Leucopenia after Metronidazole 72 reports · 2.3% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with leucopenia