Neutropenia after Doxycycline in dogs

40 reports to the FDA describe neutropenia in dogs given Doxycycline. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports

85%Marked serious

18%Recovered

33%Died or euthanised

35 daysTypical onset

How soon it started

Same day

2 5.4%

1–2 days

4 11%

3–7 days

3 8.1%

1–4 weeks

8 22%

Over a month

20 54%

How the animals did

Recovered

7 18%

Still unwell when reported

14 35%

Died

3 7.5%

Euthanised

10 25%

Not known

6 15%

Problems reported at the same time

26 65%

24 60%

21 53%

21 53%

16 40%

13 33%

13 33%

12 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause neutropenia in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 35 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

Neutropenia after Amoxicillin + Clavulanate (Clavamox) 57 reports · 1.1% of its reports
Neutropenia after Cefovecin (Convenia) 46 reports · 1.2% of its reports
Neutropenia after Enrofloxacin (Baytril) 72 reports · 1.9% of its reports
Neutropenia after Metronidazole 75 reports · 2.4% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with neutropenia