Hypoalbuminaemia after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 156 reports of hypoalbuminaemia in dogs after Amoxicillin + Clavulanate. That is 2.9% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

156Reports
56%Marked serious
6.4%Recovered
41%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
9 9.4%
1–2 days
17 18%
3–7 days
28 29%
1–4 weeks
18 19%
Over a month
24 25%

How the animals did

Recovered
9 5.8%
Recovered with lasting effects
1 0.6%
Still unwell when reported
45 29%
Died
33 21%
Euthanised
31 20%
Not known
37 24%

Problems reported at the same time

Age of the animals

Under 1 year
15
1–3 years
25
4–7 years
53
8–11 years
41
12+ years
20

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause hypoalbuminaemia in dogs?
156 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoalbuminaemia with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with hypoalbuminaemia