Hyperphosphataemia after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 129 reports of hyperphosphataemia in dogs after Amoxicillin + Clavulanate. That is 2.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

129Reports
57%Marked serious
3.9%Recovered
50%Died or euthanised
11 daysTypical onset
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How soon it started

Same day
10 12%
1–2 days
13 15%
3–7 days
17 20%
1–4 weeks
26 31%
Over a month
18 21%

How the animals did

Recovered
5 3.9%
Still unwell when reported
35 27%
Died
40 31%
Euthanised
24 19%
Not known
25 19%

Problems reported at the same time

Age of the animals

Under 1 year
22
1–3 years
14
4–7 years
27
8–11 years
34
12+ years
30

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause hyperphosphataemia in dogs?
129 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 11 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with hyperphosphataemia