Hyperphosphataemia after Amoxicillin in dogs

The FDA has received 42 reports of hyperphosphataemia in dogs after Amoxicillin. That is 3.1% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

42Reports

71%Marked serious

0.0%Recovered

40%Died or euthanised

4 daysTypical onset

How soon it started

Same day

6 21%

1–2 days

5 17%

3–7 days

5 17%

1–4 weeks

6 21%

Over a month

7 24%

How the animals did

Still unwell when reported

13 31%

Died

5 12%

Euthanised

12 29%

Not known

12 29%

Problems reported at the same time

36 86%

27 64%

25 60%

25 60%

21 50%

17 40%

16 38%

13 31%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause hyperphosphataemia in dogs?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

Hyperphosphataemia after Amoxicillin + Clavulanate (Clavamox) 129 reports · 2.4% of its reports
Hyperphosphataemia after Doxycycline 77 reports · 1.9% of its reports
Hyperphosphataemia after Cefovecin (Convenia) 77 reports · 2.0% of its reports
Hyperphosphataemia after Enrofloxacin (Baytril) 79 reports · 2.1% of its reports
Hyperphosphataemia after Metronidazole 99 reports · 3.2% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with hyperphosphataemia