Hyperkalaemia after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 54 reports of hyperkalaemia in dogs after Amoxicillin + Clavulanate. That is 1.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

54Reports

63%Marked serious

1.9%Recovered

43%Died or euthanised

21 daysTypical onset

How soon it started

Same day

4 11%

1–2 days

5 13%

3–7 days

2 5.3%

1–4 weeks

11 29%

Over a month

16 42%

How the animals did

Recovered

1 1.9%

Still unwell when reported

15 28%

Died

12 22%

Euthanised

11 20%

Not known

15 28%

Problems reported at the same time

31 57%

28 52%

27 50%

25 46%

23 43%

19 35%

19 35%

15 28%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause hyperkalaemia in dogs?: 54 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperkalaemia with similar medicines

Hyperkalaemia after Enrofloxacin (Baytril) 31 reports · 0.8% of its reports
Hyperkalaemia after Metronidazole 38 reports · 1.2% of its reports
Hyperkalaemia after Amoxicillin 23 reports · 1.7% of its reports

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with hyperkalaemia