Hyperkalaemia after Amoxicillin in dogs

23 reports to the FDA describe hyperkalaemia in dogs given Amoxicillin. That is 1.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

78%Marked serious

0.0%Recovered

39%Died or euthanised

4 daysTypical onset

How soon it started

Same day

4 22%

1–2 days

3 17%

3–7 days

3 17%

1–4 weeks

0 0.0%

Over a month

8 44%

How the animals did

Still unwell when reported

2 8.7%

Died

3 13%

Euthanised

6 26%

Not known

12 52%

Problems reported at the same time

14 61%

13 57%

13 57%

9 39%

8 35%

Hyponatremia

8 35%

Lethargy

8 35%

Vomiting

7 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause hyperkalaemia in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperkalaemia with similar medicines

Hyperkalaemia after Amoxicillin + Clavulanate (Clavamox) 54 reports · 1.0% of its reports
Hyperkalaemia after Enrofloxacin (Baytril) 31 reports · 0.8% of its reports
Hyperkalaemia after Metronidazole 38 reports · 1.2% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with hyperkalaemia