Excessive thirst after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 220 reports of excessive thirst in dogs after Amoxicillin + Clavulanate. That is 4.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

220Reports
47%Marked serious
8.2%Recovered
16%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
17 12%
1–2 days
17 12%
3–7 days
25 18%
1–4 weeks
34 24%
Over a month
47 34%

How the animals did

Recovered
14 6.4%
Recovered with lasting effects
4 1.8%
Still unwell when reported
88 40%
Died
19 8.6%
Euthanised
16 7.3%
Not known
79 36%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
12
4–7 years
63
8–11 years
77
12+ years
53

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause excessive thirst in dogs?
220 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with excessive thirst