Didn't work as expected after Praziquantel + Pyrantel in cats

The FDA has received 38 reports of didn't work as expected in cats after Praziquantel + Pyrantel. That is 3.0% of all reports for this medicine, compared with 8.7% across reports for all cat medicines, so it is reported less often than average with this medicine.

38Reports

32%Marked serious

7.9%Recovered

7.9%Died or euthanised

15 daysTypical onset

How soon it started

Same day

4 19%

1–2 days

0 0.0%

3–7 days

4 19%

1–4 weeks

7 33%

Over a month

6 29%

How the animals did

Recovered

3 7.9%

Still unwell when reported

7 18%

Euthanised

3 7.9%

Not known

25 66%

Problems reported at the same time

7 18%

5 13%

5 13%

5 13%

3 7.9%

3 7.9%

3 7.9%

2 5.3%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause didn't work as expected in cats?: 38 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Emodepside + Praziquantel (Profender) 46 reports · 0.8% of its reports
Didn't work as expected after Praziquantel 26 reports · 1.6% of its reports
Didn't work as expected after Pyrantel 37 reports · 6.6% of its reports

All reported side effects of Praziquantel + Pyrantel in cats · Medicines most reported with didn't work as expected