Elevated globulins after Emodepside + Praziquantel (Profender) in cats

20 reports to the FDA describe elevated globulins in cats given Emodepside + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported less often than average with this medicine.

20Reports

80%Marked serious

30%Recovered

25%Died or euthanised

Same dayTypical onset

How soon it started

Same day

10 56%

1–2 days

5 28%

3–7 days

1 5.6%

1–4 weeks

2 11%

Over a month

0 0.0%

How the animals did

Recovered

6 30%

Still unwell when reported

3 15%

Died

1 5.0%

Euthanised

4 20%

Not known

6 30%

Problems reported at the same time

Hyperproteinaemia

10 50%

10 50%

9 45%

8 40%

8 40%

Low platelet count

6 30%

Death

5 25%

Wobbliness (ataxia)

5 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Emodepside treats intestinal worms (spot-on for cats). Praziquantel treats tapeworms.

Products with this combination include Profender. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Emodepside + Praziquantel cause elevated globulins in cats?: 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Emodepside + Praziquantel in cats · Medicines most reported with elevated globulins