Injection site reaction after Pentosan Polysulfate Sodium in horses

The FDA has received 77 reports of injection site reaction in horses after Pentosan Polysulfate Sodium. That is 38% of all reports for this medicine, compared with 6.2% across reports for all horse medicines, so it is reported unusually often with this medicine.

77Reports
42%Marked serious
31%Recovered
0.0%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
19 27%
1–2 days
15 21%
3–7 days
6 8.5%
1–4 weeks
12 17%
Over a month
19 27%

How the animals did

Recovered
22 29%
Recovered with lasting effects
2 2.6%
Still unwell when reported
5 6.5%
Not known
48 62%

Problems reported at the same time

29 38%
10 13%
Lethargy
5 6.5%
Fever
5 6.5%
Colic
4 5.2%
Reluctant to move
4 5.2%
Tremors
4 5.2%
Lameness
4 5.2%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
7
8–11 years
19
12+ years
36

About this medicine

Type: medicine.

Questions owners ask

Can Pentosan Polysulfate Sodium cause injection site reaction in horses?
77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

All reported side effects of Pentosan Polysulfate Sodium in horses · Medicines most reported with injection site reaction