Recumbency after Moxidectin + Praziquantel in horses
The FDA has received 21 reports of recumbency in horses after Moxidectin + Praziquantel. That is 5.6% of all reports for this medicine, compared with 3.7% across reports for all horse medicines, so it is reported unusually often with this medicine.
21Reports
29%Marked serious
4.8%Recovered
29%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Praziquantel cause recumbency in horses?
- 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Recumbency with similar medicines
- Recumbency after Ivermectin + Praziquantel 77 reports · 2.9% of its reports
- Recumbency after Moxidectin (ProHeart 6) 142 reports · 10% of its reports
- Recumbency after Ivermectin (Heartgard) 66 reports · 9.6% of its reports
All reported side effects of Moxidectin + Praziquantel in horses · Medicines most reported with recumbency