Death after Moxidectin + Praziquantel in horses

47 reports to the FDA describe death in horses given Moxidectin + Praziquantel. That is 13% of all reports for this medicine, compared with 11% across reports for all horse medicines.

47Reports

72%Marked serious

0.0%Recovered

96%Died or euthanised

1 daysTypical onset

How soon it started

Same day

10 29%

1–2 days

15 43%

3–7 days

2 5.7%

1–4 weeks

5 14%

Over a month

3 8.6%

How the animals did

Died

23 49%

Euthanised

22 47%

Not known

2 4.3%

Problems reported at the same time

16 34%

11 23%

9 19%

7 15%

6 13%

Liver problems

6 13%

Didn't stop worms

5 11%

Tachycardia

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Praziquantel cause death in horses?: 47 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Ivermectin + Praziquantel 88 reports · 3.3% of its reports
Death after Moxidectin (ProHeart 6) 177 reports · 13% of its reports
Death after Ivermectin (Heartgard) 156 reports · 23% of its reports

All reported side effects of Moxidectin + Praziquantel in horses · Medicines most reported with death