Colic after Moxidectin + Praziquantel in horses

58 reports to the FDA describe colic in horses given Moxidectin + Praziquantel. That is 16% of all reports for this medicine, compared with 4.2% across reports for all horse medicines, so it is reported unusually often with this medicine.

58Reports

40%Marked serious

59%Recovered

28%Died or euthanised

1 daysTypical onset

How soon it started

Same day

21 40%

1–2 days

24 46%

3–7 days

4 7.7%

1–4 weeks

2 3.8%

Over a month

1 1.9%

How the animals did

Recovered

33 57%

Recovered with lasting effects

1 1.7%

Still unwell when reported

3 5.2%

Died

5 8.6%

Euthanised

11 19%

Not known

5 8.6%

Problems reported at the same time

16 28%

15 26%

10 17%

8 14%

6 10%

5 8.6%

Tachycardia

5 8.6%

Dehydration

5 8.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Praziquantel cause colic in horses?: 58 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Colic with similar medicines

Colic after Ivermectin + Praziquantel 71 reports · 2.7% of its reports
Colic after Moxidectin (ProHeart 6) 26 reports · 1.9% of its reports

All reported side effects of Moxidectin + Praziquantel in horses · Medicines most reported with colic