Colic after Ivermectin + Praziquantel in horses

The FDA has received 71 reports of colic in horses after Ivermectin + Praziquantel. That is 2.7% of all reports for this medicine, compared with 4.2% across reports for all horse medicines, so it is reported less often than average with this medicine.

71Reports

75%Marked serious

46%Recovered

5.6%Died or euthanised

Same dayTypical onset

How soon it started

Same day

34 62%

1–2 days

12 22%

3–7 days

4 7.3%

1–4 weeks

0 0.0%

Over a month

5 9.1%

How the animals did

Recovered

33 46%

Still unwell when reported

6 8.5%

Died

2 2.8%

Euthanised

2 2.8%

Not known

28 39%

Problems reported at the same time

18 25%

15 21%

9 13%

9 13%

7 9.9%

7 9.9%

7 9.9%

7 9.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause colic in horses?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Colic with similar medicines

Colic after Moxidectin (ProHeart 6) 26 reports · 1.9% of its reports
Colic after Moxidectin + Praziquantel 58 reports · 16% of its reports

All reported side effects of Ivermectin + Praziquantel in horses · Medicines most reported with colic