Lethargy after Moxidectin + Praziquantel in horses
The FDA has received 55 reports of lethargy in horses after Moxidectin + Praziquantel. That is 15% of all reports for this medicine, compared with 7.9% across reports for all horse medicines, so it is reported unusually often with this medicine.
55Reports
31%Marked serious
25%Recovered
13%Died or euthanised
1 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin + Praziquantel cause lethargy in horses?
- 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lethargy with similar medicines
- Lethargy after Ivermectin + Praziquantel 187 reports · 7.1% of its reports
- Lethargy after Moxidectin (ProHeart 6) 254 reports · 19% of its reports
- Lethargy after Ivermectin (Heartgard) 92 reports · 13% of its reports
All reported side effects of Moxidectin + Praziquantel in horses · Medicines most reported with lethargy