Lethargy after Moxidectin (ProHeart 6) in horses
254 reports to the FDA describe lethargy in horses given Moxidectin. That is 19% of all reports for this medicine, compared with 7.9% across reports for all horse medicines, so it is reported unusually often with this medicine.
254Reports
3.5%Marked serious
0.8%Recovered
8.3%Died or euthanised
1 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin cause lethargy in horses?
- 254 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 1 day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Lethargy with similar medicines
- Lethargy after Ivermectin + Praziquantel 187 reports · 7.1% of its reports
- Lethargy after Ivermectin (Heartgard) 92 reports · 13% of its reports
- Lethargy after Moxidectin + Praziquantel 55 reports · 15% of its reports
All reported side effects of Moxidectin in horses · Medicines most reported with lethargy