Liver problems after Clodronate Disodium in horses

The FDA has received 25 reports of liver problems in horses after Clodronate Disodium. That is 8.1% of all reports for this medicine, compared with 1.6% across reports for all horse medicines, so it is reported unusually often with this medicine.

25Reports

92%Marked serious

20%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 29%

1–2 days

9 43%

3–7 days

2 9.5%

1–4 weeks

2 9.5%

Over a month

2 9.5%

How the animals did

Recovered

3 12%

Recovered with lasting effects

2 8.0%

Still unwell when reported

1 4.0%

Euthanised

3 12%

Not known

16 64%

Problems reported at the same time

21 84%

14 56%

12 48%

10 40%

10 40%

9 36%

8 32%

Hyperglycaemia

8 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Clodronate Disodium cause liver problems in horses?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Omeprazole 20 reports · 1.0% of its reports
Liver problems after Pergolide 30 reports · 2.4% of its reports
Liver problems after Ceftiofur 25 reports · 2.1% of its reports
Liver problems after Flunixin Meglumine 21 reports · 3.4% of its reports

All reported side effects of Clodronate Disodium in horses · Medicines most reported with liver problems