Kidney problems after Clodronate Disodium in horses

95 reports to the FDA describe kidney problems in horses given Clodronate Disodium. That is 31% of all reports for this medicine, compared with 1.6% across reports for all horse medicines, so it is reported unusually often with this medicine.

95Reports

91%Marked serious

38%Recovered

6.3%Died or euthanised

1 daysTypical onset

How soon it started

Same day

13 18%

1–2 days

34 46%

3–7 days

12 16%

1–4 weeks

7 9.5%

Over a month

8 11%

How the animals did

Recovered

34 36%

Recovered with lasting effects

2 2.1%

Still unwell when reported

6 6.3%

Euthanised

6 6.3%

Not known

47 49%

Problems reported at the same time

49 52%

48 51%

47 49%

34 36%

28 29%

26 27%

22 23%

21 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Clodronate Disodium cause kidney problems in horses?: 95 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Omeprazole 21 reports · 1.1% of its reports
Kidney problems after Ceftiofur 23 reports · 1.9% of its reports
Kidney problems after Flunixin Meglumine 47 reports · 7.6% of its reports

All reported side effects of Clodronate Disodium in horses · Medicines most reported with kidney problems