Hyperkalaemia after Clodronate Disodium in horses

The FDA has received 28 reports of hyperkalaemia in horses after Clodronate Disodium. That is 9.1% of all reports for this medicine, compared with 0.4% across reports for all horse medicines, so it is reported unusually often with this medicine.

28Reports

96%Marked serious

36%Recovered

7.1%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 27%

1–2 days

10 45%

3–7 days

4 18%

1–4 weeks

0 0.0%

Over a month

2 9.1%

How the animals did

Recovered

10 36%

Still unwell when reported

2 7.1%

Euthanised

2 7.1%

Not known

14 50%

Problems reported at the same time

26 93%

20 71%

17 61%

15 54%

15 54%

13 46%

11 39%

Hyperglycaemia

9 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Clodronate Disodium cause hyperkalaemia in horses?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Clodronate Disodium in horses · Medicines most reported with hyperkalaemia