Hypercalcaemia after Clodronate Disodium in horses

35 reports to the FDA describe hypercalcaemia in horses given Clodronate Disodium. That is 11% of all reports for this medicine, compared with 0.3% across reports for all horse medicines, so it is reported unusually often with this medicine.

35Reports

89%Marked serious

34%Recovered

2.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

7 29%

1–2 days

12 50%

3–7 days

4 17%

1–4 weeks

0 0.0%

Over a month

1 4.2%

How the animals did

Recovered

10 29%

Recovered with lasting effects

2 5.7%

Still unwell when reported

2 5.7%

Euthanised

1 2.9%

Not known

20 57%

Problems reported at the same time

34 97%

22 63%

20 57%

20 57%

19 54%

15 43%

13 37%

12 34%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Clodronate Disodium cause hypercalcaemia in horses?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Clodronate Disodium in horses · Medicines most reported with hypercalcaemia