Liver problems after Omeprazole in horses

The FDA has received 20 reports of liver problems in horses after Omeprazole. That is 1.0% of all reports for this medicine, compared with 1.6% across reports for all horse medicines, so it is reported less often than average with this medicine.

20Reports
70%Marked serious
10%Recovered
40%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
2 17%
1–2 days
5 42%
3–7 days
4 33%
1–4 weeks
0 0.0%
Over a month
1 8.3%

How the animals did

Recovered
1 5.0%
Recovered with lasting effects
1 5.0%
Still unwell when reported
1 5.0%
Died
2 10%
Euthanised
6 30%
Not known
9 45%

Problems reported at the same time

8 40%
Elevated gamma-glutamyl transferase (ggt)
6 30%
Elevated creatine-kinase (ck)
6 30%
Neutrophilia
5 25%

Age of the animals

Under 1 year
3
1–3 years
0
4–7 years
3
8–11 years
2
12+ years
12

About this medicine

Type: medicine.

Questions owners ask

Can Omeprazole cause liver problems in horses?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Omeprazole in horses · Medicines most reported with liver problems