Urine abnormalities after Trilostane (Vetoryl) in dogs

The FDA has received 116 reports of urine abnormalities in dogs after Trilostane. That is 1.0% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

116Reports
71%Marked serious
4.3%Recovered
17%Died or euthanised
79 daysTypical onset
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How soon it started

Same day
1 1.3%
1–2 days
1 1.3%
3–7 days
3 4.0%
1–4 weeks
20 27%
Over a month
50 67%

How the animals did

Recovered
5 4.3%
Still unwell when reported
17 15%
Died
5 4.3%
Euthanised
15 13%
Not known
74 64%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
9
8–11 years
43
12+ years
63

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause urine abnormalities in dogs?
116 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 79 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

All reported side effects of Trilostane in dogs · Medicines most reported with urine abnormalities