High sodium-potassium ratio (na:k ratio) after Trilostane (Vetoryl) in dogs

118 reports to the FDA describe high sodium-potassium ratio (na:k ratio) in dogs given Trilostane. That is 1.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

118Reports

65%Marked serious

4.2%Recovered

11%Died or euthanised

61 daysTypical onset

How soon it started

Same day

3 3.3%

1–2 days

3 3.3%

3–7 days

7 7.7%

1–4 weeks

18 20%

Over a month

60 66%

How the animals did

Recovered

5 4.2%

Still unwell when reported

24 20%

Died

2 1.7%

Euthanised

11 9.3%

Not known

76 64%

Problems reported at the same time

52 44%

46 39%

37 31%

36 31%

32 27%

31 26%

29 25%

Abnormal adrenocorticotropic hormone (acth) stimulation test

26 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause high sodium-potassium ratio (na:k ratio) in dogs?: 118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 61 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with high sodium-potassium ratio (na:k ratio)