Addison's disease after Trilostane (Vetoryl) in dogs

139 reports to the FDA describe addison's disease in dogs given Trilostane. That is 1.2% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

139Reports

83%Marked serious

14%Recovered

19%Died or euthanised

48 daysTypical onset

How soon it started

Same day

6 5.9%

1–2 days

1 1.0%

3–7 days

9 8.9%

1–4 weeks

20 20%

Over a month

65 64%

How the animals did

Recovered

14 10%

Recovered with lasting effects

6 4.3%

Still unwell when reported

38 27%

Died

11 7.9%

Euthanised

16 12%

Not known

54 39%

Problems reported at the same time

Loss of appetite

56 40%

Lethargy

54 39%

Hyperkalaemia

52 37%

Abnormal adrenocorticotropic hormone (acth) stimulation test

41 29%

Kidney problems

41 29%

Vomiting

39 28%

Low sodium-potassium ratio (na:k ratio)

32 23%

Diarrhea

28 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause addison's disease in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 48 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with addison's disease