Abdominal mass after Trilostane (Vetoryl) in dogs

The FDA has received 49 reports of abdominal mass in dogs after Trilostane. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports

88%Marked serious

2.0%Recovered

49%Died or euthanised

64 daysTypical onset

How soon it started

Same day

3 9.1%

1–2 days

2 6.1%

3–7 days

2 6.1%

1–4 weeks

5 15%

Over a month

21 64%

How the animals did

Recovered with lasting effects

1 2.0%

Still unwell when reported

5 10%

Died

4 8.2%

Euthanised

20 41%

Not known

19 39%

Problems reported at the same time

23 47%

18 37%

16 33%

15 31%

Abnormal ultrasound finding

14 29%

Abnormal radiograph finding

12 24%

Lethargy

9 18%

Diarrhea

9 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trilostane treats Cushing's disease (an overactive adrenal gland).

Products with this ingredient include Vetoryl. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Trilostane cause abdominal mass in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 64 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Trilostane in dogs · Medicines most reported with abdominal mass