Urinary tract infection after Selamectin (Revolution) in dogs

The FDA has received 34 reports of urinary tract infection in dogs after Selamectin. That is 0.1% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

34Reports

29%Marked serious

2.9%Recovered

21%Died or euthanised

111 daysTypical onset

How soon it started

Same day

2 20%

1–2 days

1 10%

3–7 days

1 10%

1–4 weeks

1 10%

Over a month

5 50%

How the animals did

Recovered

1 2.9%

Still unwell when reported

8 24%

Died

3 8.8%

Euthanised

4 12%

Not known

18 53%

Problems reported at the same time

11 32%

10 29%

10 29%

9 26%

Microorganisms, urine

8 24%

Death

7 21%

Diarrhea

6 18%

Excessive thirst

6 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause urinary tract infection in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 111 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

Urinary tract infection after Ivermectin + Pyrantel (Heartgard Plus) 135 reports · 0.1% of its reports
Urinary tract infection after Milbemycin Oxime + Spinosad (Trifexis) 337 reports · 0.3% of its reports
Urinary tract infection after Moxidectin (ProHeart 6) 111 reports · 0.2% of its reports
Urinary tract infection after Milbemycin Oxime + Praziquantel (Interceptor Plus) 147 reports · 0.5% of its reports
Urinary tract infection after Milbemycin Oxime (Interceptor) 50 reports · 0.2% of its reports
Urinary tract infection after Ivermectin (Heartgard) 52 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with urinary tract infection