Urinary tract infection after Moxidectin (ProHeart 6) in dogs

111 reports to the FDA describe urinary tract infection in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

111Reports

59%Marked serious

8.1%Recovered

15%Died or euthanised

9 daysTypical onset

How soon it started

Same day

17 22%

1–2 days

10 13%

3–7 days

11 14%

1–4 weeks

14 18%

Over a month

25 32%

How the animals did

Recovered

9 8.1%

Still unwell when reported

65 59%

Died

13 12%

Euthanised

4 3.6%

Not known

20 18%

Problems reported at the same time

35 32%

30 27%

30 27%

26 23%

25 23%

17 15%

15 14%

14 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause urinary tract infection in dogs?: 111 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

Urinary tract infection after Ivermectin + Pyrantel (Heartgard Plus) 135 reports · 0.1% of its reports
Urinary tract infection after Milbemycin Oxime + Spinosad (Trifexis) 337 reports · 0.3% of its reports
Urinary tract infection after Milbemycin Oxime + Praziquantel (Interceptor Plus) 147 reports · 0.5% of its reports
Urinary tract infection after Milbemycin Oxime (Interceptor) 50 reports · 0.2% of its reports
Urinary tract infection after Selamectin (Revolution) 34 reports · 0.1% of its reports
Urinary tract infection after Ivermectin (Heartgard) 52 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with urinary tract infection