Blood in urine after Moxidectin (ProHeart 6) in dogs

79 reports to the FDA describe blood in urine in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

79Reports
70%Marked serious
10%Recovered
22%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
19 26%
1–2 days
11 15%
3–7 days
12 17%
1–4 weeks
10 14%
Over a month
20 28%

How the animals did

Recovered
8 10%
Still unwell when reported
46 58%
Died
6 7.6%
Euthanised
11 14%
Not known
8 10%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
16
4–7 years
31
8–11 years
20
12+ years
11

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause blood in urine in dogs?
79 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in urine with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with blood in urine