Proteinuria after Moxidectin (ProHeart 6) in dogs

The FDA has received 120 reports of proteinuria in dogs after Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

120Reports

38%Marked serious

4.2%Recovered

25%Died or euthanised

3 daysTypical onset

How soon it started

Same day

10 18%

1–2 days

18 32%

3–7 days

4 7.0%

1–4 weeks

5 8.8%

Over a month

20 35%

How the animals did

Recovered

5 4.2%

Still unwell when reported

47 39%

Died

24 20%

Euthanised

6 5.0%

Not known

38 32%

Problems reported at the same time

67 56%

60 50%

53 44%

52 43%

43 36%

43 36%

35 29%

31 26%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause proteinuria in dogs?: 120 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Ivermectin + Pyrantel (Heartgard Plus) 149 reports · 0.1% of its reports
Proteinuria after Milbemycin Oxime + Spinosad (Trifexis) 178 reports · 0.1% of its reports
Proteinuria after Milbemycin Oxime + Praziquantel (Interceptor Plus) 83 reports · 0.3% of its reports
Proteinuria after Milbemycin Oxime (Interceptor) 41 reports · 0.1% of its reports
Proteinuria after Selamectin (Revolution) 46 reports · 0.2% of its reports
Proteinuria after Ivermectin (Heartgard) 38 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with proteinuria