Haematuria after Moxidectin (ProHeart 6) in dogs

181 reports to the FDA describe haematuria in dogs given Moxidectin. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

181Reports

27%Marked serious

5.5%Recovered

36%Died or euthanised

1 daysTypical onset

How soon it started

Same day

31 42%

1–2 days

19 26%

3–7 days

8 11%

1–4 weeks

9 12%

Over a month

6 8.2%

How the animals did

Recovered

10 5.5%

Still unwell when reported

48 27%

Died

55 30%

Euthanised

10 5.5%

Not known

58 32%

Problems reported at the same time

76 42%

75 41%

71 39%

69 38%

64 35%

60 33%

56 31%

43 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause haematuria in dogs?: 181 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Haematuria with similar medicines

Haematuria after Ivermectin + Pyrantel (Heartgard Plus) 105 reports · 0.1% of its reports
Haematuria after Milbemycin Oxime + Spinosad (Trifexis) 77 reports · 0.1% of its reports
Haematuria after Milbemycin Oxime + Praziquantel (Interceptor Plus) 23 reports · 0.1% of its reports
Haematuria after Milbemycin Oxime (Interceptor) 51 reports · 0.2% of its reports
Haematuria after Selamectin (Revolution) 57 reports · 0.2% of its reports
Haematuria after Ivermectin (Heartgard) 20 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with haematuria