Tachycardia after Selamectin (Revolution) in dogs

The FDA has received 86 reports of tachycardia in dogs after Selamectin. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

86Reports

21%Marked serious

12%Recovered

22%Died or euthanised

1 daysTypical onset

How soon it started

Same day

13 45%

1–2 days

6 21%

3–7 days

5 17%

1–4 weeks

2 6.9%

Over a month

3 10%

How the animals did

Recovered

10 12%

Still unwell when reported

11 13%

Died

15 17%

Euthanised

4 4.7%

Not known

46 53%

Problems reported at the same time

36 42%

33 38%

26 30%

25 29%

25 29%

18 21%

Restlessness or agitation

13 15%

Drooling

12 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause tachycardia in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tachycardia with similar medicines

Tachycardia after Ivermectin + Pyrantel (Heartgard Plus) 204 reports · 0.1% of its reports
Tachycardia after Milbemycin Oxime + Spinosad (Trifexis) 209 reports · 0.2% of its reports
Tachycardia after Moxidectin (ProHeart 6) 628 reports · 1.2% of its reports
Tachycardia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 55 reports · 0.2% of its reports
Tachycardia after Milbemycin Oxime (Interceptor) 78 reports · 0.3% of its reports
Tachycardia after Ivermectin (Heartgard) 82 reports · 0.7% of its reports
Tachycardia after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 32 reports · 0.4% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with tachycardia