Hyperpigmentation after Selamectin (Revolution) in dogs
42 reports to the FDA describe hyperpigmentation in dogs given Selamectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.
42Reports
2.4%Marked serious
2.4%Recovered
0.0%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).
Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Selamectin cause hyperpigmentation in dogs?
- 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Hyperpigmentation with similar medicines
- Hyperpigmentation after Ivermectin + Pyrantel (Heartgard Plus) 30 reports · 0.0% of its reports
- Hyperpigmentation after Milbemycin Oxime + Spinosad (Trifexis) 50 reports · 0.0% of its reports
- Hyperpigmentation after Moxidectin (ProHeart 6) 23 reports · 0.0% of its reports
All reported side effects of Selamectin in dogs · Medicines most reported with hyperpigmentation