Gagging after Selamectin (Revolution) in dogs

The FDA has received 56 reports of gagging in dogs after Selamectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

56Reports

8.9%Marked serious

13%Recovered

3.6%Died or euthanised

Same dayTypical onset

How soon it started

Same day

16 80%

1–2 days

2 10%

3–7 days

1 5.0%

1–4 weeks

1 5.0%

Over a month

0 0.0%

How the animals did

Recovered

7 13%

Still unwell when reported

9 16%

Died

2 3.6%

Not known

38 68%

Problems reported at the same time

17 30%

15 27%

13 23%

10 18%

Didn't prevent heartworm

8 14%

Breathing problems

6 11%

Itching

5 8.9%

Tremors

5 8.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this ingredient include Revolution. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Selamectin cause gagging in dogs?: 56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gagging with similar medicines

Gagging after Ivermectin + Pyrantel (Heartgard Plus) 194 reports · 0.1% of its reports
Gagging after Milbemycin Oxime + Spinosad (Trifexis) 296 reports · 0.2% of its reports
Gagging after Moxidectin (ProHeart 6) 78 reports · 0.2% of its reports
Gagging after Milbemycin Oxime + Praziquantel (Interceptor Plus) 71 reports · 0.2% of its reports
Gagging after Milbemycin Oxime (Interceptor) 40 reports · 0.1% of its reports
Gagging after Ivermectin (Heartgard) 20 reports · 0.2% of its reports

All reported side effects of Selamectin in dogs · Medicines most reported with gagging