Gagging after Moxidectin (ProHeart 6) in dogs

78 reports to the FDA describe gagging in dogs given Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

78Reports
41%Marked serious
18%Recovered
17%Died or euthanised
Same dayTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
31 53%
1–2 days
15 26%
3–7 days
4 6.9%
1–4 weeks
4 6.9%
Over a month
4 6.9%

How the animals did

Recovered
14 18%
Still unwell when reported
36 46%
Died
9 12%
Euthanised
4 5.1%
Not known
15 19%

Problems reported at the same time

Lethargy
29 37%
Vomiting
27 35%
Cough
22 28%
Loss of appetite
21 27%
Allergic reaction
16 21%
Breathing problems
16 21%
Swelling
14 18%
Death
13 17%

Age of the animals

Under 1 year
3
1–3 years
33
4–7 years
27
8–11 years
10
12+ years
3

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause gagging in dogs?
78 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Gagging with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with gagging