Urinary incontinence after Sarolaner (Simparica) in dogs

91 reports to the FDA describe urinary incontinence in dogs given Sarolaner. That is 0.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

91Reports
58%Marked serious
16%Recovered
13%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
30 36%
1–2 days
24 29%
3–7 days
12 14%
1–4 weeks
8 9.5%
Over a month
10 12%

How the animals did

Recovered
15 16%
Still unwell when reported
43 47%
Died
5 5.5%
Euthanised
7 7.7%
Not known
21 23%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
18
4–7 years
19
8–11 years
27
12+ years
16

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause urinary incontinence in dogs?
91 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

All reported side effects of Sarolaner in dogs · Medicines most reported with urinary incontinence