Urinary incontinence after Afoxolaner (NexGard) in dogs
The FDA has received 276 reports of urinary incontinence in dogs after Afoxolaner. That is 0.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.
276Reports
55%Marked serious
27%Recovered
9.1%Died or euthanised
4 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Afoxolaner kills fleas and ticks; given as a monthly chewable.
Products with this ingredient include NexGard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Questions owners ask
- Can Afoxolaner cause urinary incontinence in dogs?
- 276 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 4 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Urinary incontinence with similar medicines
- Urinary incontinence after Fluralaner (Bravecto) 275 reports · 0.4% of its reports
- Urinary incontinence after Sarolaner (Simparica) 91 reports · 0.5% of its reports
- Urinary incontinence after Lotilaner (Credelio) 69 reports · 0.7% of its reports
All reported side effects of Afoxolaner in dogs · Medicines most reported with urinary incontinence