Not drinking after Sarolaner (Simparica) in dogs

The FDA has received 113 reports of not drinking in dogs after Sarolaner. That is 0.7% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

113Reports

46%Marked serious

28%Recovered

12%Died or euthanised

1 daysTypical onset

How soon it started

Same day

37 37%

1–2 days

39 39%

3–7 days

15 15%

1–4 weeks

1 1.0%

Over a month

8 8.0%

How the animals did

Recovered

32 28%

Still unwell when reported

45 40%

Died

6 5.3%

Euthanised

7 6.2%

Not known

23 20%

Problems reported at the same time

103 91%

68 60%

28 25%

24 21%

20 18%

19 17%

16 14%

15 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause not drinking in dogs?: 113 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Fluralaner (Bravecto) 487 reports · 0.7% of its reports
Not drinking after Afoxolaner (NexGard) 382 reports · 0.7% of its reports
Not drinking after Lotilaner (Credelio) 118 reports · 1.2% of its reports
Not drinking after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 52 reports · 0.6% of its reports
Not drinking after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 33 reports · 1.1% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with not drinking